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Medicamento ciprofloxacin 250 mg


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\ Antibiotics \


  • Generic name: Levofloxacin
  • Brand names: Levaquin, Tavanic; Oftaquix, Quixin, Iquix
  • Dosages:
    Tablets 250 mg, 500 mg, 750 mg;
    Solution, oral 25 mg/mL;
    Injection (concentrate) 500 mg (25 mg/mL), 750 mg (25 mg/mL);
    Injection (premix) 250 mg (5 mg/mL), 500 mg (5 mg/mL), 750 mg (5 mg/mL).
  • Pharmacologic category: Fluoroquinolone antibiotic
  • FDA approved: December 20, 1996
  • Pregnancy risk factor: C

Medical uses

Levofloxacin is a powerful fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and atypical pathogens.

Levofloxacin indicated uses include:

  • Respiratory Tract Infections: community-acquired pneumonia (CAP), hospital-acquired pneumonia, ciprofloxacin acute exacerbations of chronic bronchitis (AECB), acute sinusitis.
  • Genitourinary Tract infections: chronic bacterial prostatitis, uncomplicated UTI, acute pyelonephritis, complicated UTI
  • Complicated and uncomplicated skin and soft tissue infections

The most common levofloxacin side effects medicamento ciprofloxacin 250 mg are nausea, diarrhea, headache, insomnia, and dizziness 4.

Pharmacological characteristics

Benefits

Concerns

Unlabeled uses

Mode of action

Levofloxacin is the L-isomer of the racemate, ofloxacin, a quinolone antibiotic. The antibacterial activity of ofloxacin resides primarily in the L-isomer. The mechanism of action of levofloxacin and other fluoroquinolone antimicrobials involves the inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are Type II topoisomerases), enzymes required for DNA replication, transcription, repair, and recombination.

As the S (-) enantiomer of the fluoroquinolone, ofloxacin, levofloxacin, inhibits DNA-gyrase in susceptible organisms thereby inhibits relaxation of supercoiled DNA and promotes breakage of DNA strands. DNA gyrase (topoisomerase II), is an essential bacterial enzyme that maintains the superhelical structure of DNA and is required for DNA replication and transcription, DNA repair, recombination, and transposition.

Reviews & Discussions

References

Written by HealthyStock.net, October 2009
Last updated: February, 2016

Interesting facts


Levofloxacin 500 mg
  • In Europe, levofloxacin is marketed by Sanofi-Aventis under the trade name of Tavanic®, and in Asia it is marketed by Daiichi under the trade name of Cravit®.
  • As levofloxacin has a high oral bioavailability (about 99%) it is appropriate for intravenous-to-oral sequential treatment.
  • Chemically, levofloxacin is the S-enantiomer (L-isomer) of ofloxacin, and has approximately twice the potency of ofloxacin.

Source: http://www.healthystock.net/drugs/levofloxacin.shtml


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