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\ Antibiotics \
Levofloxacin is a powerful fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and atypical pathogens.
Levofloxacin indicated uses include:
The most common levofloxacin side effects are nausea, diarrhea, headache, insomnia, and dizziness 4.
Mode of action
Levofloxacin is the L-isomer of the racemate, ofloxacin, a quinolone antibiotic. The antibacterial activity of ofloxacin resides primarily in the L-isomer. The mechanism of action of levofloxacin and other fluoroquinolone antimicrobials involves the inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are Type II topoisomerases), enzymes required for DNA replication, transcription, ciprofloxacin 500 mg uti repair, and recombination.
As the S (-) enantiomer of the fluoroquinolone, ofloxacin, levofloxacin, inhibits DNA-gyrase in susceptible organisms thereby inhibits relaxation of supercoiled DNA and promotes breakage of DNA strands. DNA gyrase (topoisomerase II), is an essential bacterial enzyme that maintains the superhelical structure of DNA and is required for DNA replication and transcription, DNA repair, recombination, and transposition.
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Written by HealthyStock.net, October 2009
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